Anaspec has expanded its MMP product line with a suite of Sensolyte MMP Elisa kits.
Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases involved in both normal and diseased tissue remodelling.
They are capable of degrading all kinds of extracellular matrix (ECM) proteins, but also can process a number of bioactive molecules.
MMPs are key players in normal and pathological processes, including embryogenesis, wound healing, inflammation, arthritis, and cancer.
MMPs share common structural and functional elements and are products of different genes.
The three common domains include the pro-peptide, the catalytic domain and the haemopexin-like C-terminal domain, linked to the catalytic domain by a flexible hinge region.
MMPs are initially synthesised as inactive (latent) zymogens with a pro-peptide domain that must be removed before the enzyme is active.
The Sensolyte MMP Elisa kits from Anaspec are suitable for quantitative detection of MMP proteins (latent and active forms) in serum, plasma, cell culture supernates and urine.
The kits use a 96-well-plate-based format with colorimetric readout.
Anaspec's fluorescent Sensolyte MMP activity assays measure active MMPs in a 96-well-plate-based method with highly-sensitive fluorimetric readout.
A colorimetric readout MMP activity assay kit is also available.