The new Modulus Multi-Detection Microplate and Single-Tube reader are available from Labtech International.
The Modulus combines the superior performance expected from single-mode instruments with the functionality of multiple modes.
To achieve high performance, it is designed with optical channels dedicated to each individual technology.
Unlike other multimode systems, readings taken with the Modulus are not degraded by indirect fibre-optic transmission or crowded optical channels.
Dedicated optical channelling ensures that the Modulus provides sensitivity and dynamic range on par with single-mode instruments.
The Modulus is designed to be put into use straight from the box without the need to read a manual or obtain special training.
To achieve this plug-and-play usability, the Modulus combines a colour touch-screen with an intuitive user interface.
The interface makes running samples and viewing data fast and simple while also maintaining the flexibility needed for advanced or custom protocols.
The Modulus can be purchased as a luminometer, then fluorescence and/or absorbance modules can be purchased and added later.
There's no service call or downtime.
With the modular design, changing technologies is as easy as snapping in a module and restarting the instrument.
The Modulus with a luminescence module is designed to deliver performance equivalent to dedicated single-tube luminometers while also offering the flexibility of a multimode reader.
To achieve sensitivity on par with that of a dedicated luminometer, the luminescence channel is separated from other measurement technologies and positioned directly below the sample well.
These conditions maximise light capture for the best-possible sensitivity.
In conjunction, a low-noise photomultiplier tube ensures that collected light is not compromised.
The Modulus also has greater than 5 logs of dynamic range.
This dynamic range is more than adequate to cover common luminescence applications, thus reducing the need to dilute samples.
To achieve high performance, each fluorescence module utilises powerful light-emitting diodes (LEDs) as excitation sources.
LEDs have very specific light-output profiles that closely match the excitation profile of commonly used fluorescent molecules.
LED usage increases sensitivity by fully exciting the fluorophore and reducing non-specific light leakage, a problem often found when using broad spectrum light sources.
Additionally, the highly sensitive Modulus uses a 90deg fluorescent design to minimise light scatter and lower background resulting in high sensitivity.
The Modulus as a fluorometer utilises four easily exchangeable modules to measure the most popular fluorophores.
The Modulus with the absorbance Module provides measurements that are highly sensitive and cover a wide dynamic range.
Because the optics are not shared with any other detection technology, the focused absorbance measurements yield outstanding performance.
The absorbance channel has a large reading range of 0-4 OD with an accuracy that deviates less than 0.7 per cent.
The Modulus comes with three filter paddles with factory-installed filters for measuring 560, 600, and 750nm.
These filters accommodate the most common protein assays.
Filter paddles can be easily exchanged in seconds.
In addition, custom filter paddles can be readily made for non-standard applications.
