LGC Forensics has announced that it has helped solve the first-ever murder case appeal by the BBC's 'Crimewatch' programme using modern DNA forensic techniques.
In June 1984, the programme appealed to the public for information that might help Nottinghamshire police solve the murder of 16-year-old Colette Aram.
A reconstruction of the investigation that led to the conviction in February of Aram's killer was shown on BBC One's 'Crimewatch' on 27 January.
In November 2007, LGC Forensics was approached by the Nottinghamshire police to assist them with their re-investigation of the case.
In particular, LGC was asked to extend the analysis of cellular material (blood and semen) found on a paper tissue thought to be associated with the murder.
An earlier investigation by scientists from another provider had established that the material analysed did not match the DNA profile of anyone on the UK National DNA Database (NDNAD).
The first step was to determine whether there were any 'near misses' on the NDNAD, which might indicate the presence of a family member.
LGC Forensics used a new familial searching technique, developed in its research laboratories, which provided a list of people - identified from the 'near misses' on the NDNAD and prioritised according to how similar their DNA profiles were to the one from the material analysed.
The LGC scientists then used another advanced DNA technique known as Y-STRs to provide more information.
Y-STRs are passed down the male line, from father to son, and they therefore provide powerful links between males in the same family.
The top 300 names on the prioritised list from the NDNAD were then also tested for Y-STRs, but there were no matches with the Y-STRs in the material on the tissue.
As more samples were added to the database, more individuals were prioritised and tested for Y-STRs.
Eventually, after samples from approximately 600 males had been analysed, one of them was found to match the Y-STR profile from the tissue.
This immediately threw the spotlight onto this person's family and, on 7 April 2009, reference samples were taken from his father - Paul Hutchinson - and two of his uncles, Hutchinson's brothers.
Time was of the essence because clearly only one of the three men could have been responsible for the material on the tissue.
The samples were delivered by helicopter to LGC's Runcorn laboratory in Cheshire where DNA reference samples such as these are analysed in a dedicated facility.
The DNA team rapidly processed them and interpreted, confirmed and reported the results to Nottinghamshire police all within nine hours.
In January 2010, Paul Hutchinson was found guilty of the murder of Colette Aram and sentenced to a minimum jail term of 25 years.
