SP Scientific has announced a Lyolearn webinar that will discuss the critical product parameters and environmental factors that affect freeze-drying scale-up procedures.
The rational development and optimisation of freeze-drying cycles in the laboratory should be based on knowledge of the critical formulation parameters, such as the collapse temperature.
Once a recipe has been finalised that ensures acceptable product temperatures throughout the process, the transfer to manufacturing scale can be initiated.
The aim of this scale-up step should be to closely imitate the product temperature profile obtained in the laboratory to ensure comparable product quality.
To achieve this, several important factors have to be taken into consideration.
Chaired by Dr Stefan Schneid of the University of Erlangen, Freeze Drying Focus Group, the scope of the webinar will be to discuss the most important parameters in freeze-drying scale-up such as nucleation behaviour, differences in heat transfer, plus freeze-dryer design and performance and their impact on product quality.
Methods to evaluate and compensate differences between freeze dryers and the use of placebo or fractional loads for preliminary studies will also be evaluated.
SP Scientific's programme of free educational webinars devoted to freeze-drying topics follow a 30-minute format for the presentations with a QandA session immediately afterwards.
The webinar takes place on 17 June 2010.
