AnaSpec, Eurogentec Group, has highlighted its collection of Fmoc- and Boc-protected amino acids, modified through polyethylene glycol (PEG), for PEGylated peptides synthesis used for drug delivery.
PEGylation has become a well-accepted method for the delivery of biopharmaceuticals, especially peptide and protein drugs.
Simple modification of a drug with polyethylene glycol (PEG) not only is capable of improving the drug's solubility, diminishing the potential for aggregation, and minimising interference for both in-vitro and in-vivo applications, but is also able to protect it from proteolytic digestion, increasing its half life in biological applications in the process.
Custom synthesis of PEGylated peptides is available through AnaSpec's Fremont, California facilities.
