SP Scientific has announced a Lyolearn webinar that will discuss the role of controlled ice nucleation in quality by design (QBD) freeze-drying scale-up procedures.
The webinar, which is set for 27 January 2011, will be chaired by Prof Michael J Pikal, professor and distinguished chair - pharmaceutical technology at the University of Connecticut.
The scope of the webinar will be to discuss controlled ice nucleation by both the ice-fog technique and the depressurisation technique and to review the advantages of controlled ice nucleation.
To practice quality by design, organisations must be able to scale-up freeze-drying results generated in the laboratory to full-scale manufacturing.
To do this, a technique must address a number of heat and mass transfer scale-up issues.
The webinar will suggest methodology for estimating the changes to a laboratory procedure that are required.
In addition, the webinar will address the scale-up challenges presented by the difference in ice nucleation temperatures between the laboratory and the Class 100 environment found in manufacturing.
Greater degrees of super-cooling are typically found in manufacturing, meaning manufacturing processes run longer and run hotter than in the laboratory.
Operators may minimise the freezing difference between laboratory and manufacturing by annealing in the frozen state, but perhaps the best strategy is to control the ice nucleation temperature.
In this webinar, the author discusses controlled ice nucleation by both the ice-fog technique and the depressurisation technique and reviews the advantages of controlled ice nucleation.
SP Scientific's programme of free webinars follow a 30-minute format for the presentations with a QandA session immediately afterwards.
