SP Scientific has announced the 2011 dates for its hands-on laboratory training courses in freeze-drying methods, designed to enable those involved with lyophilisation to gain knowledge and network.
Lyophilisation Cycle Development and Optimisation: A Laboratory Based Approach is a hands-on training course delivered by Dr Jeff Schwegman with guest lecturer, Dr Michael Pikal, which will focus on following the freeze-drying process from formulation and thermal analysis to cycle development and optimisation, packaging and troubleshooting.
Attendees will have the chance to optimise their learning experience by using tangible applications in a controlled setting.
Freeze Dry Cycle Development and Optimisation Using a Design Space Approach is a hands-on training course delivered by Dr Steven Nail and Lisa Hardwick designed to enable participants to develop and optimise a primary drying cycle using a design space approach that includes both product imposed and equipment imposed limitation on the process.
Two PAT tools (TDLAS and MTM) facilitate the measurement of vial heat-transfer coefficients and resistance of the dry layer to flow of water vapour.
These values are used, in conjunction with heat and mass-transfer equations, to compute the design space.
This approach minimises trial-and-error experimentation and gives optimal cycle conditions, which are defined as conditions that provide a maximum sublimation rate that is within the capability of the equipment and produces a pharmaceutically acceptable product.
