Denator has launched the Stabilizor Peptide Extraction Kit, which enables users to heat-stabilise, homogenise and extract endogenous peptides from tissue samples prior to analysis by LC-MS.
During downstream analysis, the presence of endogenous peptides, often existing at very low levels in vivo, can be masked by peptide fragments generated from normal degradation processes.
Utilization of Denator's Stabilizor system, based on the company's heat-stabilisation technology, has been shown to stop tissue degradation from the moment of sampling, preventing the enzymatic processes that generate peptide fragments.
Denator expects this news will be of particular interest to researchers looking at the role of neuropeptides in neurogenerative diseases.
A recently published paper demonstrated an increased recovery of neuropeptides from tissue samples when utilising heat stabilisation followed by an optimal extraction protocol.
According to Denator, this kit offers the convenience of having all necessary accessories ready to use and includes a validated protocol, which aims to maximise the recovery of endogenous, water-soluble peptides for subsequent analysis by LC-MS.