Anaspec claims to provide the industry's largest collection of anti-Tau antibodies - 23 phosphospecific and 14 non-phosphospecific Tau antibodies.
A custom service for the production of AD related peptides and antibodies is also available.
These Tau rabbit polyclonal antibodies, raised against Tau peptides, are supplied as epitope- affinity purified rabbit IgG at 25 or 50ug sizes at 0.2mg/ml of 1xPBS solution.
Species reactivity includes human, mouse and rat, and some antibodies have also shown reactivity with bovine, chicken and zebrafish.
Tau is a collection of microtubule-associated proteins that is involved in microtubule assembly and stabilisation.
In a human adult brain, six isoforms, ranging between 352 and 441 amino acids in length, are produced as a result of alternative RNA splicing.
The expression of Tau isoforms is developmentally regulated, as only the smallest Tau polypeptide is expressed in the fetal brain.
Hyperphosphorylated Tau is the major component of the paired helical filament of Alzheimer's disease.
Anti-phospho-Tau antibodies are used to identify specific amino acids that are phosphorylated in Tau from normal brains and Alzheimer's disease brains.
The Tau proteins, especially in developing brains and in Alzheimer brains, are phosphorylated in vivo at many different sites such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Ser400, Ser404 and Ser413.
