Malvern will showcase its Morphologi G3-ID particle characterisation system at Drug Delivery to the Lungs 23.
The company will highlight the system’s ability to generate component-specific particle size and shape data to support the commercialisation of both new and generic Orally Inhaled and Nasal Dry Products (OINDPs).
Activities at the conference will include a poster presentation that details results from a new study in which the Morphologi G3-ID was used to successfully measure nasal sprays in the formulated liquid state with minimal sample preparation.
The Morphologi G3-ID combines imaging technology with Raman spectroscopy to generate size, shape and chemical identification data from a single platform.
In OINDP characterisation, it complements Malvern’s laser diffraction instruments for rapid particle size measurement – the Mastersizer 3000 and Spraytec – and other techniques such as cascade impaction, by reliably differentiating even morphologically identical particles to generate data for specific formulation components.
According to the company, the Morphologi G3-ID therefore presents an efficient solution for applications such as:
- Foreign contaminant detection
- Verification of active ingredient particle size pre- and post- delivery for nasal suspensions
- Detailed investigation of the delivered particle size of dry powder inhaler actives
The Malvern Instruments poster presentation for DDL 23 is ‘Measuring the particle size of the active components of nasal sprays in the formulated liquid state’.
It details a methodology for wet measurement that extends efficient application of the Morphologi G3-ID beyond dry powder characterisation.
Company experts will be on hand throughout the conference to discuss the work and more generally how Malvern’s analytical instruments work in tandem to support the evolution of OINDP technology.
Drug Delivery to the Lungs 23 is taking place from 5 – 7 Dec 2012 in Edinburgh, Scotland.
To learn more about the technology, please click on the link above.
