Biomarkers to be developed into a screening test to identify women at risk for premature birth from intra-amniotic infection
ProteoGenix, a company with expertise in genomics and proteomics applied to biomarker discovery, has selected Bruker Daltonics as a strategic partner for the development of high-throughput protein biomarker discovery and mass spectrometry based multi-analyte assay platforms.
One of ProteoGenix's recent successes was the discovery of biomarkers for intra-amniotic infection, published in the Journal of the American Medical Association.
ProteoGenix intends to develop these biomarkers into a screening test to identify women at risk for premature birth from the infection.
Development of such a non-invasive test may allow treatment early enough to prevent premature birth and has the potential to prevent up to an estimated 175,000 premature births that occur annually in the USA due to intra-amniotic infection.
Under their collaboration, the companies will collaborate to implement the ProteoGenix protein biomarker discovery methods on the Bruker Daltonics Autoflex II Tof/Tof instrument.
The teams plan to increase the speed, efficiency and throughput of the protein biomarker discovery methods by employing Bruker Daltonics' magnetic bead based ClinProt platform for automatic processing of serum samples, as well as samples of other body fluids.
Other aspects of the collaborative effort will be the use of ClinProTools comprehensive analysis, visualisation and statistical model building software for biomarker discovery, and ProteinScape software to manage the data processing and archiving from the protein biomarker discovery workflow.
Srinivasa Nagalla, chief scientific officer and acting COO of Proteogenix, commented: "We were delighted to find a partner that can provide a complete solution for protein biomarker discovery and identification, including high performance Maldi Tof/Tof mass spectrometers, together with robotics for automation and high throughput, and the software tools required for data analysis and workflow management. "We look forward to working with Bruker Daltonics to implement our methods on their instrumentation".
Gary Kruppa, vice president of Bruker Daltonics, stated: "We are very pleased that ProteoGenix, a high profile and successful protein biomarker discovery company, has chosen us as their strategic partner.
"Such customers validate our approach to developing a complete solution to biomarker discovery and identification.
"We look forward to a fruitful collaboration with ProteoGenix that will assist us in the further development of our biomarker discovery solutions."
