The ArrayScan HCS system from Cellomics is a proprietary drug discovery instrument that performs automated measurement and analysis of spatial and temporal events in cells
Based upon novel High Content Screening (HCS) technology developed by Cellomics, the ArrayScan HCS system automatically provides reliable insight into the efficacy and toxicity of new drug candidates.
Using multi-colour fluorescence-based reagents the ArrayScan HCS system is able to follow and quantify the activity of components in living cells.
It is the measurement of these complex cellular responses, analysed using sophisticated proprietary image-based algorithms, that provides the additional critical knowledge to accurately determine which targets to investigate and which lead compounds to pursue.
The ArrayScan's unique optical path is optimised for performing rapid automated scans through the bottom of clear-bottomed microplates.
The system automatically focuses on a field of cells and acquires images at each selected colour channel.
The ArrayScan software identifies and measures individual features and structures within each cell in a field of cells, such that hundreds of cells are productively analysed in parallel.
The software then tabulates and presents the results in user defined formats.
All raw data, including images of individual cells, are archived and available for inspection and analysis.
The ArrayScan HCS system provides tremendous benefits in many areas including target validation, drug candidate optimisation, and early predictive toxicology.
Raw data and images generated by the ArrayScan may be automatically transferred into a computer database for further data mining using a suite of informatics products.
The ArrayScan HCS system can be purchased separately or can be integrated into a full-spectrum lead optimisation programme that includes assay development, HitKit HCS reagents, cell supply agreements, and information management tools.
