LC Packings, a Dionex company, offers a full range of Nano HPLC columns, especially for use in combination with NanoSpray/MS, said to improve mass sensitivity by a factor of 5000
The packed columns are characterised by a high efficiency, outstanding column-to-column reproducibility and ease of use. They are available in a wide variety of chemistries, ranging from typical phases such as reversed-phase C18, to polar phases such as silica.
The Nano Series of columns can be supplied with 50, 75 and 100µm ID, designed for flow rates, ranging from 50 up to 1000nl/min.
A typical example for the use of Nano columns is their coupling to NanoFlow ES/MS.
Modern Electrospray interfaces can operate under flow rates less than 1µl/min, providing highest sensitivity.
Using Nano HPLC columns easily improves the mass sensitivity by a factor of up to 5000, when compared to 4.6mm ID columns with conventional flow rates.
