Cartridges with shorter columns enable faster LC separations for greater throughput; longer use cartridges allow analysis of more samples using a single device
Nanostream, a provider of high-throughput microfluidic analytical systems, announces the availability of two new 24-column Brio cartridges to be used with the Nanostream Veloce micro parallel liquid chromatography (mPLC) system to perform routine HPLC analyses.
The second-generation cartridges enable faster separations and longer usage.
Nanostream employs microfluidic technology in its Brio cartridges, which enable multiple samples to be analysed in parallel for increased throughput while reducing sample and solvent consumption.
Each polymer-based reusable cartridge incorporates twenty-four columns packed with standard (C18) stationary phase material to achieve reverse phase separations.
Cartridges are inserted into Nanostream's Veloce mPLC system where 24 samples are analysed simultaneously, eliminating the need for traditional HPLC columns.
Customers may select cartridges to fulfill their throughput requirements and to optimise performance for their specific experimental protocols. Shorter column shortens cycle time.
By reducing the column length, Nanostream's 3cm column Brio cartridge allows faster separations.
In comparison to Nanostream's first-generation cartridge, the 3cm column Brio cartridge is ideal for high-throughput applications such as separation-based assays, which require the separation of a product from a substrate, for example.
Typical analysis time could be 15 seconds per sample, including automated sample introduction via the system's eight-head autosampler.
The shorter column dimensions are 30mm in length by 0.5mm inner diameter.
Cartridge life extended to increase number of samples analysed using a single device. Nanostream's 100-use Brio cartridges enable 2400 liquid chromatography separations.
Compared to Nanostream's initial cartridge, there is a six-fold increase in number of analyses conducted with one cartridge.
The 100-use Brio cartridges are available in both 3cm column and 8cm column cartridge formats. "Our innovative microfluidic technology is helping scientists in drug discovery and development to achieve greater throughput with confidence in data reproducibility, saving them a lot of time and overhead costs," said Gene Dantsker, vice president of technology at Nanostream.
"This platform provides enormous flexibility, so we can rapidly prototype new cartridges.
"There are endless possibilities to the range of cartridges we can design."
