Targets are used to identify low molecular weight compounds in matrix assisted laser desorption ionisation (Maldi) mass spectrometers
Kratos Analytical, a subsidiary of Shimadzu, and NanoHorizons have announced the commercial introduction of a fast, precise technique for small molecule analysis.
Kratos will offer NanoHorizons's disposable QuickMass targets, which are used to identify low molecular weight compounds in Maldi (matrix assisted laser desorption ionisation) mass spectrometers, through Shimadzu Biotech.
Users of the Axima-QIT and Axima-CFRplus line of mass spectrometry systems will soon be able to realise the benefits of high throughput and lower cost from using matrix-less, QuickMass targets for small molecule analysis. QuickMass targets increase selectivity and reduce cross-contamination concerns for small molecule detection in Maldi-type mass spectrometers.
"QuickMass targets are a breakthrough in mass spectrometry: they provide clean and reproducible low molecular weight spectra by eliminating the matrix compound used to help laser desorption/ionisation in a Maldi mass spectrometer.
"This dramatic improvement is due to the QuickMass target's non-porous, thin film surface, which adsorbs and transfers the laser energy to the sample molecules.
"Accordingly, the interfering background matrix peaks that are commonly observed with Maldi MS are not present. "Also, the lack of surface porosity prevents low mass contaminant trapping" says Stephen Fonash, founder and chairman of NanoHorizons.
"By reducing the cost and increasing sample throughput, our technology makes applications such as drug discovery more cost effective" adds Robert Burlinson, NanoHorizons's president and CEO.
"Further, our targets do not degrade with exposure to the atmosphere, so they can be stored without extraordinary precautions.
"And, since QuickMass plates are low cost, they can be discarded or retained for reanalysis".
Chris Sutton, Maldi business manager for Shimadzu Biotech, stated: "The QuickMass targets represent an opportunity to demonstrate the versatility of the Axima mass spectrometers, enabling the company to present new solutions to the pharmaceutical and chemical markets. "QuickMass targets are a part of Shimadzu Biotech's continuing strategy for developing a series of modified Maldi targets that provide improved performance in a diverse range of applications."
