Cyclin A2 is important in the transition to DNA synthesis and replication phases of the cell cycle and is abruptly destroyed as the cell moves into mitosis
Beckman Coulter introduces the IOTest Anti-Cyclin A2 monoclonal antibody, for the study of cell cycle transitions in life science research.
This FITC-conjugated antibody is the newest addition to Beckman Coulter's universal cytometry reagent line, which works on all instrument platforms, including the company's Cell Lab Quanta and FC 500 MPL flow cytometers.
Cyclin A2 is important in the transition to DNA synthesis and replication phases of the cell cycle and is abruptly destroyed as the cell moves into mitosis.
Cyclin A2 is present in proliferating somatic cells, and its absence indicates that the cell is no longer replicating.
The expression and diminishing expression of cyclin A2 are thought to play a prominent role in tumorigenesis.
The new IOTest Anti-Cyclin A2 monoclonal antibody is useful in a wide range of applications including basic research on cell cycle control, apoptosis and tumorigenesis; clinical cancer studies; and pharmaceutical discovery efforts to identify inhibitors, blockers and antimitotic drugs.
"This new antibody is an exciting addition to our line of over 3200 cellular analysis research reagents," commented Michel Pagniez, cellular analysis product manager for Beckman Coulter.
"As a leading supplier of flow cytometry instruments and reagents, we offer a full line of tools for applications ranging from basic research to clinical diagnostics".
The preformulated, standardised IOTest Anti-Cyclin A2 monoclonal antibody is provided in 100-test vials.
It is ready to use, adapted for permeabilisation procedures such as cold methanol or IntraPrep with a wash, and may be used in multi-colour applications with cell markers and DNA-content dyes such as 7-aminoactinomycin D (7-AAD) or propidium iodide.
Beckman Coulter is a manufacturer of biomedical testing instrument systems, tests and supplies that simplify and automate laboratory processes.
Its 200,000 installed systems provide essential biomedical information to enhance healthcare around the world.
Based in Fullerton, California, it reported 2004 annual sales of $2.4 billion with 64% of this amount generated by recurring revenue from supplies, test kits and services.