Used primarily for investigating in vivo metabolite profiles, splitting and pooling reduces the number of radio-HPLC analyses and therefore the time taken to complete studies
Debra 5.6, the latest release of LabLogic's Lims for drug metabolism, has freed radio-chromatographers creating pooled samples from the drudgery and potential errors of manual data transfer.
Used primarily for investigating in vivo metabolite profiles, splitting and pooling reduces the number of radio-HPLC analyses and therefore the time taken to complete studies - but until now the only way of calculating results was to cut and paste into Excel data from the Lims and the RC data system, such as Lablogic's Laura 3.3.
Users can create pooled samples in Debra by group, gender or timepoint and select samples to include by the required percentage recovery of dose.
In its latest version, Debra can exchange data with the Laura radio-chromatography software such that selected batches of pooled and split samples can be exported for analysis and then results re-imported to Debra as evaluated chromatograms.
There is no need to validate that data from the two applications refer to the same sample.
Concentration or percentage recovery figures from Debra are automatically linked to Laura's percentages for each metabolite, and the two are combined to produce the final report.
Debra holds the data that allows pools to be traced back to their original constituent samples, and stores LSC/weight information for possible further processing and calculations.
