PTM Discovery System incorporates electron transfer dissociation (ETD) in Bruker's HCTultra high-capacity ion trap mass spectrometer, the world's only system with fully integrated ETD capability
At Pittcon 2006, Bruker Daltonics announced the release of a powerful, novel PTMscan on its PTM Discovery System.
The PTM Discovery System incorporates electron transfer dissociation (ETD) in Bruker Daltonics's highly successful HCTultra high-capacity ion trap mass spectrometer, said to be the world's first and only commercial system with fully integrated ETD capability.
ETD fragmentation breaks the peptide backbone non-ergodically and preserves functionally important post-translational modifications (PTMs), such as phosphorylation and glycosylation.
The newly introduced PTMscan can now detect PTMs by first screening for specific neutral losses during collision-induced dissociation (CID), and then triggering automatic, data-dependent ETD experiments on the fly.
A particularly important PTMscan, called Phospho-PTMscan enables the automated detection and localization of phosphorylations of peptides and small proteins.
Similar Glyco-PTMscan methods are supported as well.
Michael Schubert, Executive Vice President of Bruker Daltonics, commented: "Last year, we introduced the world's first high-capacity ion trap with ETD capability.
"This year, the PTMscan methods further extend our customers' ability for automated, intelligent phosphorylation and glycosylation characterization.
"While similar PTM-analysis capabilities have been available on our apex-Qe FTMS systems, PTMscan now also enables this important branch of proteomics on our robust, ultra-high sensitivity ion traps.
"This further establishes Bruker Daltonics as the leader in PTM and proteomics research by mass spectrometry".
