For improved analysis of pharmaceutical compounds at low temperatures, Polymer Laboratories has launched a new option for its PL-ELS 2100 evaporative light scattering detector (ELSD)
For improved analysis of pharmaceutical compounds at low temperatures, Polymer Laboratories, now a part of Varian, has launched a new option for its PL-ELS 2100 evaporative light scattering detector (ELSD), the PL-ELS 2100 Ice (integrated cooled evaporator).
In order to meet the requirements for pharmaceutical analysis of non-UV absorbing, low molecular weight semi-volatile analytes, for example, drug candidates, ELSDs must be operated at low temperatures in order to maximize detection for these compounds.
To reduce the operating temperature to below ambient for low molecular weight, low boiling point compounds, eg, short chain hydrocarbons, Polymer Laboratories has introduced the unique option of sub-ambient operation to provide greater sensitivity.
The PL-ELS 2100 Ice operates at temperatures down to 10C.
The detector applies a stream of dry nitrogen during the evaporation step to reduce the relative humidity of the surroundings.
The addition of evaporation gas not only allows low temperature operation with aqueous mobile phases but also facilitates the removal of water at sub-ambient temperatures.
This provides high sensitivity detection of semi-volatile compounds and a more universal response across all compounds.
