Ghrelin, a 28-amino-acid peptide hormone produced by the stomach in mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity)
In 1999, Kojima and his group reported the discovery of a growth hormone secretagogue that is involved in the release of growth hormone from the anterior pituitary through activation of the growth hormone secretagogue receptor (GHS-R) which they termed Ghrelin (ghre from a Proto-Indo-European root meaning to grow).
Ghrelin, a 28-amino-acid peptide hormone produced by the stomach in mammals, is a peptide with an n-octanoyl modification at Ser3 (n-octanoylation is essential for its activity).
It stimulates appetite and food intake and decreases fat utilisation.
The secretion of ghrelin is augmented under conditions of both gastric emptying and filling, and its release stimulated by intestinal hormones.
In 2005, Hsueh's group found a peptide fragment from the same ghrelin gene that has opposite effects from those of Ghrelin.
This they named Obestatin (obedere from Latin, meaning to devour, and statin denoting suppression).
Obestatin binds to the orphan G protein-coupled receptor GPR39 and suppresses food intake, inhibits jejunal contraction and decreases body weight gain.
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