AnaSpec now offers custom synthesis service of peptide-aminoluciferin substrates
Aminoluciferin (aLuc) is luciferin with its six-position hydroxyl group substituted with an amino group.
This modification allows aLuc to form peptide (amide) bonds with a peptide, while at the same time retaining the transport and bioluminescent properties of luciferin, resulting in a molecule called peptide-aminoluciferin.
Many peptides-aminoluciferin are good substrates for luciferase-based (bioluminescence) assays.
These substrates generally offer significant advantages, such as increased sensitivity, ease of use, and high throughput screening capacity.
Luciferase-based assays are typically 10- to 100-fold more sensitive than comparable fluorescent assays (rhodamine 110, AMC and AFC).
