Biofocus DPI has announced the launch of seven biologically targeted libraries of drug-like compounds.
These libraries specifically target ion channels, kinases and proteases - three of the most important protein classes for drug discovery.
The design of the first two Softfocus protease libraries (SFP01 and SFP02) is targeted at cysteine and serine proteases and is based upon structures of more than 50 protease-ligand complexes available from the Protein Data Bank, providing key insights into a potentially widely applicable protease scaffold template.
Two Softfocus ion channel libraries (SFI11 and SFI12) have been designed using Helical Domain Recognition Analysis (HDRA), which links X-ray, sequence alignment and SAR data.
HDRA is used to rationalise scaffold binding in the pore region of ion channels and to guide monomer selection.
Two Softfocus kinase libraries (SFK52 and SFK53) have also been launched.
The Fieldfocus kinase library (FFK03) tackles kinase library design from a ligand perspective.
The FFK libraries are based on a new in-silico, fragment-based approach, leading to suitable matches between a series of fragments and the bioactive conformation of a potent kinase inhibitor.
