Copley Scientific has developed a range of compact instruments for testing transdermal drug delivery systems.
This includes two units, the HDT 10 and the HDT 1, based on the vertical diffusion (or Franz) cell, a method for in vitro testing of topical semi-solid drug-forms, such as creams, ointments and gels.
Streamlined heating systems and a novel clamping arrangement simplify equipment set-up and enhance measurement accuracy.
The HDT 10 accommodates 10 diffusion cells in a single aluminium heating block.
It contains powerful magnetic stirrers beneath each test station.
A single control panel controls, sets and displays stirrer speed and temperature.
The heating block design gives stable temperature control and eliminates the spaghetti of tubing associated with more-conventional water-jacketed cells.
The HDT 1 is a smaller, lower cost unit with just a single cell.
It is useful during early phase evaluation studies when there is little material available and the testing burden is lighter.
The cell design is identical to the HDT 10 and incorporates a three-pronged spring clamp that makes it easier to eliminate air bubbles during test set-up.
Copley Scientific is also offering rotating paddle and paddle-over-disc accessories, for use with traditional dissolution testers (USP Methods 5 and 6), for those employing alternative transdermal testing strategies.
