Biofocus DPI, a provider of gene-to-drug candidate discovery services, has introduced six new biologically targeted libraries.
These new libraries contain novel drug-like compounds that specifically target ion channels, kinases and proteases.
The Softfocus ion channel library (SFI13) has been designed using Biofocus DPI's Helical Domain Recognition Analysis (HDRA) approach, which links X-ray, sequence alignment and SAR data.
HDRA rationalises scaffold binding in the pore regions of ion channels and guides monomer selection.
Softfocus ion-channel libraries have a track record of delivering potent and selective compound series against a variety of ion channel drug targets.
Biofocus DPI's four new Softfocus kinase libraries (SFK54, SFK55, SFK56 and SFK57) have been developed to target hinge, DFG-out and novel binding modes.
The SFK collection has been independently determined to have the greatest population of kinase-like molecules available for screening.
Biofocus DPI's new Softfocus protease library (SFP03) targets cysteine and serine proteases.
It is designed using a technique based on structures of more than 50 protease-ligand complexes available from the Protein Data Bank, providing a potentially widely applicable protease scaffold template.
