A publication on Toxoplasma gondii (T gondii), an apicomplexan parasite, has cited the use of a T gondii antibody and protein from Meridian Life Science (MLS).
In their publication, entitled 'Azurin-like protein blocks invasion of Toxoplasma gondii through potential interactions with parasite surface antigen SAG1', authors Arunasalam Naguleswaran et al demonstrated that azurin and azurin-like protein (Laz) is a potent inhibitor of T gondii.
Testing included the use of two MLS products: catalogue number C65203M, a monoclonal antibody to T gondii (FITC conjugated), was used in an immunofluorescence assay; and catalogue number R18426, T gondii P30 (SAG1), a recombinant protein, was used in surface plasmon resonance analysis.
T gondii is a serious complication in immunocompromised individuals such as Aids patients and can be the cause of congenital birth defects in newborns of infected mothers.
Azurin, the cupredoxin-family protein produced by Pseudomonas aeruginosa, exhibits the ability to impede invasion of a number of diverse intracellular pathogens.
Examples of pathogens that are blocked by this protein include Human Immunodeficiency Virus Type 1 (HIV-1) and Plasmodium falciparum (malaria).
