Roche Applied Science has launched the CIM-Plate 16 for its Xcelligence System, used for cell analysis in cancer research.
The 16-well culture plate features electronic sensors for the direct study of cell migration and invasion on the Xcelligence RTCA DP Instrument.
The system delivers unbiased data, without disturbing cells due to labelling, and allows researchers to monitor cell invasion and migration continuously in real-time throughout the duration of the experiment.
The user can combine E-Plate 16 to measure cell proliferation and CIM-Plate 16 to quantify cell migration and invasion.
The system measures electrical impedance across interdigitated micro-electrodes integrated on the bottom of tissue-culture E-Plates.
The impedance measurement provides quantitative information about the biological status of the cells, including cell number, viability and morphology.
The CIM-Plate 16 is a single-use, disposable device for performing cell-invasion and cell-migration assays on the RTCA DP Instrument.
The CIM-Plate 16 is comprised of a plate cover (lid), an upper chamber and a lower chamber.
The upper chamber has 16 wells that are sealed at the bottom with a microporous polyethylene terephthalate (PET) membrane.
Microfabricated gold electrode arrays are located on the bottom side of the membrane, which has a median pore size of 8um.
The lower chamber has 16 wells, each of which serves as a reservoir for media and any chemoattractant for the cells in corresponding upper-chamber wells.
The CIM-Plate 16 Assembly Tool can be used to assemble the lower and upper chambers once the media has been added.
