Trevigen has announced the availability of 19 DNA repair gene knockdown cell lines for scientists to study the molecular etiology of tumour genomic instability and to exploit it in oncology research.
These are target-specific LN428 glioblastoma shRNA lentivirus transduced cells that are rigorously qualified and mycoplasma free.
The per cent knockdown levels are determined by RT-PCR.
Lentiviruses are maintained by puromycin selection.
DNA repair proteins maintain the stability of the genome.
When repair protein function is impaired through mutations, the genome may become unstable, which is a hall mark of solid tumours.
This first panel of knockdown cell lines covers the Base Excision Repair pathway.
