Thermo Fisher Scientific has introduced the Thermo Scientific Orbitrap Elite, a hybrid mass spectrometer that offers resolving power of 240,000, for applications in proteomics, metabolomics and more.
The Orbitrap Elite hybrid mass spectrometer integrates Thermo Scientific's faster, more sensitive ion trap, the Thermo Scientific Velos Pro, with the company's new high-field Orbitrap and advanced signal-processing technologies.
The system offers a range of fragmentation techniques intended to help customers explore and address complex challenges in proteomics, metabolomics, lipidomics and metabolism applications.
It can be seen in the Thermo Scientific hospitality suite at the Hyatt Regency in Centennial Ballroom D during the 59th Annual ASMS Conference on Mass Spectrometry and Allied Topics, from 5-9 June in Denver.
The Orbitrap Elite embodies multiple technologies, including new ion-transfer optics that improve ion-beam transmission into the Orbitrap mass analyser and a new image current pre-amplifier.
In addition, new Velos Pro ion-trap technology, such as linear detection electronics, fast scanning and neutral-blocking front-end ion optics, serve to enhance overall system quantitative performance, speed and uptime.
For bottom-up proteomics experiments, the Orbitrap Elite is claimed to offer laboratories greater proteome coverage through improved protein, PTM and peptide identification, even at low abundances.
For quantitative proteomics, its higher system speed and sensitivity increase the number of quantifiable peptides when using isobaric labelling methods such as tandem mass tags (TMT).
For metabolomics, lipidomics and metabolism studies, the Orbitrap Elite is claimed to offer high-quality HCD and MSn spectra, providing richer structural information for unambiguous metabolite identification.
Compared to previous systems, its high sensitivity enables detection of more metabolites and other important sample components.
The system's high resolution makes it suitable for resolving isobaric species, such as those required for the analysis of lipids.
