Charged aerosol detection is a robust HPLC detection technology that delivers advanced capabilities of interest to every HPLC user-lab
ESA has released new applications data demonstrating that its Corona charged aerosol detector (Cad) for HPLC can provide consistently high sensitivity and low limits of detection independent of molecular structure.
With its superior capacity to reliably measure compounds present in low nanogram quantities, the Corona Cad routinely provides ten times the sensitivity of evaporative light scattering (ELS) detection, ESA claims.
Charged aerosol detection is a robust HPLC detection technology that delivers advanced capabilities of interest to every HPLC user-lab.
Besides excellent sensitivity, ESA says the Corona Cad shows consistent inter-analyte response independent of chemical structure, enabling quantitation across a range that exceeds four orders of magnitude.
This first, real universal detector can also effectively analyse a wide diversity of chemical structures and classes.
Corona Cad's revolutionary technology is said to be applicable for measuring virtually any non- or semi-volatile compound such as drug compounds, carbohydrates, steroids, proteins, lipids, peptides and sugars.
The groundbreaking method can be used effectively in a wide range of industries: pharmaceutical, industrial chemical, polymer, food and life science research.
With charged aerosol detection, the HPLC column eluent is nebulised and the resulting droplets dry at ambient temperature producing analyte particles.
A second stream of gas is positively charged as it passes a high-voltage, platinum corona wire.
The charged gas collides with and transfers charges to the opposing stream of analyte particles.
A negatively charged, low-voltage ion trap removes high-mobility particles while analyte particles transfer their charges to a collector.
The charge transferred to the collector is in direct proportion to analyte mass.
