Thermo Electron has introduced QuickQuan software for automating high-throughput LC-MS/MS assays in early drug discovery.
Thermo Electron has introduced QuickQuan software for automating high-throughput LC-MS/MS assays in early drug discovery.
The combination of QuickQuan's rapid compound tune and optimisation time with Thermo's Finnigan TSQ Quantum triple quadrupole mass spectrometer is key to automatically assessing new chemical entities (NCEs) in early drug development assays, such as metabolic stability, says the company.
QuickQuan delivers rapid LC-MS/MS optimisation through use of an automated on-line infusion mode and valve switching design.
This allows for precise auto-tuning with high sensitivity that, consequently, maximises successful automated quantification of chemically diverse compounds.
All analytical information is stored either in Microsoft Access or Oracle databases, which facilitates rapid data exchange across global networks.
"Pharmaceutical researchers tell us that manual LC-MS/MS method development can be time consuming for analysts considering, for example, that it may take as long as five to ten hours to process 30 compounds," said Dr Lester Taylor, global product marketing director, Life Sciences Mass Spectrometry for Thermo.
"Thermo's QuickQuan minimises manual intervention and significantly increases productivity in demanding, high-throughput applications such as CACO-2 assays by as much as 75%".
