Otava and Life Chemicals present the new human Phosphatidylinositol 3-Kinase (PI3K) focused library with 2189 compounds
This library has been created as a part of a joint project aimed at design of a large set of receptor-based sharp-focused libraries.
In the framework of this project, Life Chemicals provides its Collection of 300,000 compounds and subsequent chemical optimization.
Otava provides its drug-like Green Collection (50,000 compounds) and also is responsible for molecular modeling tasks.
Design of the focused libraries consists in Lipinsky/Veber rules filtering and flexible docking in a protein target of certain enzyme family.
Further computational analysis for the presence of critical receptor-ligand hydrogen bond(s) and docking score refinement makes our focused libraries good starting point for drug discovery purposes.
In case of this library detection of H-bonding between ligand and key PI3K hinge region residue (Val882) was used for its preparation.
Otava supplies fine organic chemicals including unique building blocks for combinatorial organic synthesis.
We provide compound libraries for screening, custom synthesis, molecular modeling services, targeted compound libraries and protein kinase inhibitors, prescreened anticancer compounds, peptide and chromogenic substrates.
Established in Kiev, Ukraine, in 1995 as a private small business, Life Chemicals has dynamically expanded and developed to become an internationally recognised producer and supplier of HTS compounds and related services.
The company operates world-wide and its main office is located in Burlington, Canada.
This year the Company proudly celebrates its ten year anniversary as an advanced laboratory to synthesise drug-like and lead-like HTS compounds, targeted libraries, core building blocks and carry out custom synthesis.
Life Chemicals employs high skills and abilities of over 80 professionals.
It also takes advantage of its co-operation with leading 14 universities, academic and industrial laboratories of Ukraine, being the largest exporter of Ukrainian high-tech products.
