Bruker BioSpin announced two innovations in CryoProbe product at Pittcon 2004 - TCI CryoProbe (triple-resonance inverse with carbon observe), and HCP CryoProbe (for hydrogen, carbon and phosphorus)
These CryoProbes are ideal for structural biology research on proteins and nucleic acids.
Bruker BioSpin is the pioneer and clear market leader in cryogenically cooled NMR probe technology, with more than 300 CryoProbes delivered since 1999.
CryoProbes improve the sensitivity of NMR spectrometers by 300 to 400%.
The new TCI CryoProbe does the work of two probes.
Its proton-carbon-nitrogen capabilities deliver conventional proton-observed inverse NMR data, used for protein structure determination, with the added benefit of high-sensitivity carbon detection.
Carbon detection is important for challenging applications such as very large and paramagnetic proteins.
Ideal for proteomics research, this TCI CryoProbe provides both proton and carbon data on a single sample, eliminating the need for time-consuming probe changes.
Available for the Avance 500 and 600MHz NMR systems, the TCI CryoProbe will enable expanded applications of NMR in the study of large molecules.
The new HCP CryoProbe is the first cryogenically cooled NMR probe that offers proton-carbonphosphorus capabilities, for DNA and RNA structural biology research.
The inclusion of phosphorus nuclei measurement in NMR experiments facilitates sequential assignments, which are critical in the study of DNA and RNA molecules.
Available for Avance 500 and 600MHz NMR systems, the HCP CryoProbe delivers the higher sensitivity that is critical for structure determination on nucleic acids.
"These new capabilities exemplify our ongoing leadership in CryoProbe technology advancements," commented Clemens Anklin, vice president for applications of Bruker BioSpin.
"We are continually working with the research community and tailoring new CryoProbe designs to meet their evolving needs."
