Chemical imaging system supports understanding of how component distribution, particle sizes and additional component spatial characteristics can impact a complex dosage form
Spectral Dimensions reports recent successes in assessing novel drug dosage forms with the Sapphire chemical imaging system.
The spatial and chemical complexity of a controlled release tablet is readily visualised in a chemical image, acquired with the Sapphire system.
This chemical image intuitively represents the relative distribution of the active pharmaceutical ingredient (API) and excipients throughout the tablet, says the company.
The Sapphire chemical imaging system supports understanding of how component distribution, particle sizes and additional component spatial characteristics can impact a complex dosage form - its formulation, manufacturability, stability, and ultimate physical characteristics.
Sapphire can chemically image and quantitatively assess the actual chemical structure of sophisticated advanced drug delivery systems.
Near infrared (NIR) chemical imaging is employed to assess the physical distribution and characteristics of chemical components.
This is particularly critical information in characterising advanced dosage forms, for which physical structure is as critical as chemical composition.
For cored tablets, Sapphire can assess the coating quality, by measuring thickness, uniformity, and other coating characteristics.
For microspheres or coated spheres, the system enables manufacturing quality assurance, through high throughput monitoring of the uniformity of coating thickness, microsphere mean diameter, and the relative composition of mixtures of different types of microspheres.
For transdermal patches, stents and implants, Sapphire characterises the uniformity of active ingredients on the supporting substrate.
For osmotic pumps, Sapphire generates time-resolved analysis of the pump performance.
Spectral Dimensions says Sapphire is the only comprehensive chemical imaging solution appropriate for the assessment of a variety of properties of advanced dosage forms.
For assessment of the performance of advanced drug delivery systems, near infrared chemical imaging with a Sapphire system can provide critical and unique benefits, it adds.
