Anaspec has released a range of cell-penetrating peptides (CPPs), also known as protein transduction domains (PTDs), which are carriers with small peptide domains that can cross cell membranes.
Several PTDs have been identified that allow a fused protein to efficiently cross cell membranes in a process known as protein transduction.
Studies have demonstrated that a TAT peptide derived from the HIV TAT protein has the ability to transduce peptides or proteins into various cells.
Anaspec's GO Peptides include a vast offering of CPPs.
These include CPPs such as (Arg)9, Antennapedia, TAT and others.
Offerings include green fluorescent labelled (for example FAM or FITC) CPP, red labelled (for example TAMRA), Cys conjugated CPPs or Cys (Npys) conjugated CPP.
Npys stands for 3-nitro-2-pyridinesulfenyl.
Npys activates the thiol group of another cysteine-containing peptide, forming a disulfide bond between the two.
This results in the conjugation of the CPP with the peptide cargo.
