BAC has introduced its Captureselect Humanplasma14, which enables the highly specific, reproducible depletion of the 14 most abundant proteins from human blood plasma or serum.
Humanplasma14 is designed for single-step, single-use depletion of more than 99 per cent of the abundant proteins.
The resulting sample can then be used for further downstream applications including gel electrophoresis and mass spectrometry.
Humanplasma14 is the first product from BAC's Captureselect Proteomics Toolbox, which consists of a mixture of Captureselect ligands.
Captureselect ligands are single-domain monospecific antibodies immobilised on high-capacity agarose-based beads, which have been proven in laboratory and large-scale industrial applications and can be custom combined for specific protein depletion needs, said BAC.
The slurry can be pre-packed into columns or used in custom-made formats.
'The single-use format of Humanplasma14 avoids the common problems associated with column recycling, such as clogging, bead regeneration and potential contamination of precious samples,' said Prof Marina Hincapie of Northeastern University.
'Being able to support a loading capacity of 20-30ul/ml means that there is less sample dilution and we experience better recovery and reproducibility compared to competitive products,' she added.
