Engineered version of wild-type DNase I has markedly increased affinity for DNA, giving a functional advantage in RT-PCR
Turbot DNase is an engineered version of wild-type DNase I that has markedly increased affinity for DNA.
This is important for complete removal of DNA from a sample, since the concentration of the cleavable substrate is reduced as the DNase digestion progresses.
Thus, Turbo DNase has a functional advantage over wild-type DNase in RT-PCR applications, where even a few copies of DNA can lead to a false positive outcome by PCR.
