Tight junction proteins are specialised regions of cell-cell contact that prevent ions, water and other molecules from leaking from between cells, and maintain epithelial cell-polarity
Zymed's recently extended range of tight junction antibodies is available in the UK from Cambridge BioScience.
Tight junction proteins are specialised regions of cell-cell contact that prevent ions, water and other molecules from leaking from between cells, and maintain epithelial cell-polarity.
Zymed's large, highly-characterised line of cell junction antibodies includes the integral membrane proteins claudins and occludins, and peripheral membrane proteins zonula occludens.
Claudins have been identified as major cell adhesion molecules working at tight junctions.
Cambridge BioScience offers ten different claudin antibodies.
The new polyclonal Jay.8 antibody is highly specific for Claudin-1, and does not cross-react with Claudin-3.
Claudin antibodies have applications in Elisa, Western blot and immunofluorescence.
Occludins are suggested to play a role in the organisation and dynamic function of the epithelial tight junction.
Zymed occludin antibodies are useful for many immunoassays.
Zymed polyclonal Z-T122 antibody reacts specifically with occludin and is excellent for Elisa, Western blot, immunofluorescence and immunoprecipitation applications. Zonula occludens homologues, ZO-1 and ZO-2, can be found at tight junctions in both epithelial and endothelial cells and also at adheren junctions in fibroblasts.
They belong to the membrane-associated guanylate kinase-containing family (Maguk). Monoclonal and polyclonal anti-ZO-1 and polyclonal anti-ZO-2 are available from Cambridge BioScience.
