Fluorous products are novel chemical and sorbent tools that facilitate the synthesis and separation of organic molecules and biopolymers during library generation in drug discovery research
Sigma-Aldrich and Fluorous Technologies announce the availability of FTI products from Sigma Aldrich.
Fluorous chemicals and sorbent products can now be purchased using the 2005/2006 Fluka Catalogue or 2005/2006 Aldrich Handbook and online. "Fluorous chemistry improves productivity through efficient purification," said Hans-Jurgen Kohlbau, product manager organics at Sigma-Aldrich.
"We are excited to offer our customers a broad range of novel products for this unique technology showing great promise in both green chemical process development and the entire drug discovery and development process".
Fluorous products are novel chemical and sorbent tools that facilitate the synthesis and separation of organic molecules and biopolymers during library generation in drug discovery research.
They enable an easy, scaleable work-up of reaction mixtures and the recovery and recycling of expensive catalytic species.
Fluorous methods are attractive and easy to apply because the experimental techniques (solution phase reactions, liquid-liquid extractions, solid phase extractions) are familiar to practicing organic chemists, says Sigm-Aldrich. In addition to being compatible with a wide variety of chemical reactions, fluorous chemistry is also compatible with several new synthesis technologies, like automated high throughput parallel synthesis, the use of supercritical CO2, and microwave synthesis. Fluorous synthesis and separation is the subject of a ChemFiles newsletter from Sigma Aldrich, which is widely respected as a resource for products and technical information associated with important new technologies.
The upcoming issue, Vol 4 No 9, displays Sigma-Aldrich's entire line of products for fluorous synthesis and separation.
Fluorous systems are nearly as straightforward as resins, offering a general, robust, selective, and orthogonal separation method to isolate products from reaction mixtures.
Unlike resins, however, fluorous chemistry also features the kinetic efficiency of solution-phase, the ability to do in-process analytical monitoring, and access to the full lexicon of familiar solution-phase reactions.
A wide range of solution-phase organic reactions can be adapted to exploit fluorous advantages without change to the synthetic strategy.
As a true homogeneous support, fluorous tags can even be used in transformations that are not accessible when using solid-phase approaches.
"We are very pleased to have Sigma-Aldrich as our distribution partner.
"Its reputation for technical expertise, quality, and customer service, not to mention the fact that nearly every laboratory in the world has its catalogues, creates a strong link between customers and our advanced separation chemistry products," said Philip Yeske, CEO of Fluorous Technologies
