And this microplate cytometer now has a single violet laser excitation source for beta-Lactamase and blue fluorescent protein reporter systems
Following the success of the 488nm Acumen Explorer, TTP LabTech has launched a model with a single violet (405nm) laser excitation source.
The new Acumen Explorer 405nm model enables the beta-Lactamase and blue fluorescent protein reporter systems which, until now, have routinely been measured by bulk fluorescence readers as single point readouts.
In contrast, Acumen Explorer offers multi-parametric analysis at high throughput allowing rapid, high content assays.
By fully exploiting the ratiometric detection of fluorescent enzyme substrates on a cell-by-cell basis, Acumen Explorer 405 provides greater assay sensitivity on plate formats ranging from 96 to the 1536 and 3456 microplates used in uHTS.
In addition, Acumen Explorer 405 offers enhanced compatibility with quantum dots as it increases the intensity of fluorescent emission by up to four-fold compared to its sister instrument.
Use of quantum dots expands the multiplexing capability of the Acumen Explorer, particularly in immunological detection methodologies. "Acumen Explorer with a 405nm excitation source equips the drug discovery community with newly accessible technologies, providing an additional range of high content, high speed and highly sensitive cell-based assays" said Wayne Bowen, TTP LabTech's chief scientific officer.
"These innovations underpin our continued investment in fluorescence instrumentation to support existing and future customers".
Already adopted by major pharmaceutical and biotechnology companies, the Acumen Explorer laser-scanning fluorescence microplate cytometer enables the development and execution of powerful cell-based, high content screens.
The system offers what TTP says is unparalleled throughput flexibility in a wide range of cell-based assays.
