These prepacked columns enable convenient purification or removal of highly hydrophobic proteins and offer different selectivities for small-scale media screening and purification
GE Healthcare has introduced HiTrap Butyl-S FF (1ml and 5ml) prepacked columns designed to meet the growing need for pure proteins in both research and process development.
HiTrap Butyl-S FF 1ml column is also included in the updated HiTrap HIC selection kit now expanded to six hydrophobic interaction (HIC) media with different selectivities for small-scale media screening and purification.
"The newest addition to the HiTrap HIC selection kit broadens screening of hydrophobic proteins and offers varying selectivities for optimal purification.
"This tools allows for fast, convenient screening to help researchers choose the most appropriate Sepharose HIC media when scaling up to the manufacturing level," said Allan Simpson, vice president of marketing research and analysis, protein separations at GE Healthcare.
"In a convenient, reliable format for fast and easy separations, the HiTrap columns provide highly reproducible results and consistent quality".
HiTrap Butyl-S FF is prepacked with Butyl-S Sepharose 6 Fast Flow, a hydrophobic chromatographic medium designed for purification of relatively strong hydrophobic molecules at low salt concentrations.
The medium is useful for removal of strongly hydrophobic contaminant because it is the least hydrophobic of GE Healthcare's HIC media.
The matrix Butyl-S Sepharose 6 Fast Flow is based on cross-linked agarose with a butyl ligand containing a sulphur atom, which means the ligand density can be accurately measured to secure reproducible production of the media.
With a flexible design, HiTrap Butyl-S FF can be used with a syringe, a simple laboratory pump or a chromatography system, such as Aktadesign or FPLC system.
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