Anaspec has introduced its range of Histone Go Peptides, including sequences that are acetylated and di- or tri-methylated.
The core histones (H2A, H2B, H3 and H4) act as spools around which DNA winds.
Covalent modification on the amino terminal of the core histones through de/acetylation, de/methylation and de/phosphorylation affect chromatin structure and exquisitely regulate gene expression.
Histone hyperacetylation is correlated with increased transcription, whereas hypoacetylation correlates with transcriptional repression.
