Using a SP Scientific LyoStar, GILYOS GmbH is set to participate in a research program called FORMOsA.
FORMOsA focuses on age-related muscle atrophy (sarcopenia).
In this project, GILYOS will be actively involved in the formulation development and freeze drying process design and optimisation of follistatin for subcutaneous application.
Follistatin is a messenger substance which is present in almost all types of tissue.
The protein effectively inhibits myostatin which, in turn, plays a key role in skeletal muscle atrophy. Follistatin might therefore be a promising substance for treating sarcopenia.
To optimise the freeze dried dosage form, GILYOS will use the Lyostar Freeze Drying system to investigate partially crystalline formulations as such mixtures allow short process times.
The SP Scientific LyoStar3 is a freeze-dryer that claims to provide unmatched process accuracy, reliability and unique ease-of-use features.
For applications ranging from process development for scale-up to product processing for stability studies to formulations work the LyoStar delivers consistent results other freeze dryers cannot match.
The LyoStar features RTD-controlled shelf temperature accuracy of /- 0.5°C or better and vacuum control within 0.1% of set-point. Its robust 5.5 hp cascade refrigeration system enables shelf pull down from ambient to –40°C in less than 25 minutes, and the ultra-reliable scroll compressors feature just 3 moving parts.