Said to provide the most comprehensive source of mouse genomic data combined with a high sensitivity, integrated system for gene expression analysis
Applied Biosystems has announced the commercial availability of its mouse genome survey microarray for use with its recently introduced expression array system, a highly sensitive gene expression detection system that, the company says, detects more genes and achieves more than a ten-fold increase in sensitivity for the detection of low expressed genes when compared to conventional fluorescent microarrays.
"The Applied Biosystems mouse genome survey microarray complements our recently commercialised human genome survey microarray and is a further example of our commitment to provide superior performance for the study of genome-wide expression analysis," said Michael Hunkapiller, president of Applied Biosystems. "Researchers now have the most comprehensive, integrated solution for mouse expression analysis, including the ability to easily move from whole-genome analysis to gene quantification and single-gene analysis using our mouse expression array system in conjunction with our TaqMan mouse gene expression assays, TaqMan low density array, Celera Discovery System, and real-time PCR systems".
The mouse genome survey microarray contains probes representing a complete, annotated, and fully curated set of approximately 32,000 mouse genes from the public and Celera databases.
Employing the same highly sensitive chemiluminescence technology and well-defined, 60mer probe lengths as the Applied Biosystems human genome survey microarray, the mouse microarray is said to provide the most comprehensive source of mouse genomic data for researchers studying the mouse, an important animal model of disease used also for safety assessment of therapeutics in toxicology studies.
In addition, the annotation file supplied with the mouse microarray provides pre-computed human-mouse ortholog pairs for each gene when available.
By obtaining a license to the Celera Discovery System online platform, researchers using the Celera Map Viewer can access graphical displays to compare human and mouse genes within their genomic context, and to identify genes located on the same chromosome and whether there is demonstrable linkage between them.
The Applied Biosystems rat genome survey microarray is in development, and is expected to be available later in 2004.
